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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472004Generated: October 28, 2026

Tryptamine → 2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyrimidin-4-amine

https://huagongshe.com/reaction/1472004

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTryptamineHCID 1150—
Reactant4-Chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidineHCID 86668796—
Product2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyrimidin-4-amineHCID 68156984—

Reaction Steps

This compound can be prepared by reacting tryptamine with 4-chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidine as described in Example 36.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09012462B2
Source datasetuspto-grants-2015_04
ORD IDord-f05048d995d54e16b7ce2a12caedb606
Source noteuspto-grants-2015_04