Tryptamine → 2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyrimidin-4-amine

HRID 1472004Notes

Reaction equation

HRID 1472004 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.Cl[C:14]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][N:17]=[C:16]([C:24]2[C:29]([O:30][CH3:31])=[N:28][C:27]([P:32]([CH3:35])([CH3:34])=[O:33])=[CH:26][N:25]=2)[N:15]=1>>[CH3:35][P:32]([C:27]1[N:28]=[C:29]([O:30][CH3:31])[C:24]([C:16]2[N:17]=[C:18]([NH:1][CH2:2][CH2:3][C:4]3[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[NH:6][CH:5]=3)[C:19]([C:20]([F:22])([F:23])[F:21])=[CH:14][N:15]=2)=[N:25][CH:26]=1)([CH3:34])=[O:33]

Participants

3

Reactant 2

HCID 1150TryptamineHCID 866687964-Chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidine

Product 1

HCID 681569842-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyrimidin-4-amine

Procedure

This compound can be prepared by reacting tryptamine with 4-chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidine as described in Example 36.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-f05048d995d54e16b7ce2a12caedb606
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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