(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide → N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine

HRID 1472005Notes

Reaction equation

HRID 1472005 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:5]=[CH:4][N:3]=1.[CH3:21][P:22]([C:25]1[N:30]=[C:29]([O:31][CH3:32])[C:28]([NH2:33])=[CH:27][CH:26]=1)([CH3:24])=[O:23]>>[CH3:24][P:22]([C:25]1[N:30]=[C:29]([O:31][CH3:32])[C:28]([NH:33][C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:5]=[CH:4][N:3]=2)=[CH:27][CH:26]=1)([CH3:21])=[O:23]

Participants

3

Reactant 2

HCID 67052694(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxideHCID 866687912-Chloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine

Product 1

HCID 68165233N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine

Procedure

This compound can be prepared as in Example 32 by reacting 2-Chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-pyrimidin-4-amine with 6-(dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32).

Workup

  1. customThis compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-81f0ef03214e42d993d314e00031deb5
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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