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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472005Generated: October 28, 2026

(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide → N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine

https://huagongshe.com/reaction/1472005

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxideHCID 67052694—
Reactant2-Chloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amineHCID 86668791—
ProductN2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamineHCID 68165233—

Reaction Steps

This compound can be prepared as in Example 32 by reacting 2-Chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-pyrimidin-4-amine with 6-(dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09012462B2
Source datasetuspto-grants-2015_04
ORD IDord-81f0ef03214e42d993d314e00031deb5
Source noteuspto-grants-2015_04