1-Amino-4-methylpiperazine → HCID 68157021, compound

HRID 1472041Notes

Reaction equation

HRID 1472041 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([P:15]([CH3:18])([CH3:17])=[O:16])=[CH:11][CH:10]=2)[CH:3]=1.[NH2:19][N:20]1[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]1>>[CH3:17][P:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:4]2[CH:3]=[C:2]([NH:19][N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[N:7]=[CH:6][N:5]=2)=[CH:10][CH:11]=1)([CH3:18])=[O:16]

Participants

3

Reactant 2

HCID 813491-Amino-4-methylpiperazineHCID 866688076-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine

Product 1

HCID 68157021HCID 68157021, compound

Procedure

The compound is prepared as in Example 59 by reacting 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine with 1-Amino-4-methyl-piperazine.

Workup

  1. customThe compound is prepared as in Example 59

Sources & evidence

ORD record
ord-26cdd6618e8846c8830fd19e845766ee
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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