5-(Dimethylphosphoryl)-2-methoxyaniline → N2-[5-(dimethylphosphoryl)-2-methoxyphenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

HRID 1472059Notes

Reaction equation

HRID 1472059 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[C:5]([C:21]([F:24])([F:23])[F:22])=[CH:4][N:3]=1.[CH3:25][P:26]([C:29]1[CH:30]=[CH:31][C:32]([O:36][CH3:37])=[C:33]([CH:35]=1)[NH2:34])([CH3:28])=[O:27]>>[CH3:28][P:26]([C:29]1[CH:30]=[CH:31][C:32]([O:36][CH3:37])=[C:33]([NH:34][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[C:5]([C:21]([F:24])([F:23])[F:22])=[CH:4][N:3]=2)[CH:35]=1)([CH3:25])=[O:27]

Participants

3

Reactant 2

HCID 670526575-(Dimethylphosphoryl)-2-methoxyanilineHCID 866688142-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine

Product 1

HCID 68166194N2-[5-(dimethylphosphoryl)-2-methoxyphenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

Procedure

This compound can be prepared as described in Example 80 by reacting 2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine with 5-(Dimethylphosphoryl)-2-methoxyaniline.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-06dfef1790384b95a51d907086c2a5d5
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

Loading…