(4-Amino-3-chlorophenyl)dimethylphosphine oxide → N2-[2-chloro-4-(dimethylphosphoryl)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

HRID 1472066Notes

Reaction equation

HRID 1472066 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[C:5]([C:21]([F:24])([F:23])[F:22])=[CH:4][N:3]=1.[Cl:25][C:26]1[CH:32]=[C:31]([P:33]([CH3:36])([CH3:35])=[O:34])[CH:30]=[CH:29][C:27]=1[NH2:28]>>[Cl:25][C:26]1[CH:32]=[C:31]([P:33]([CH3:35])([CH3:36])=[O:34])[CH:30]=[CH:29][C:27]=1[NH:28][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:16])=[O:17])[C:5]([C:21]([F:24])([F:22])[F:23])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 67052677(4-Amino-3-chlorophenyl)dimethylphosphine oxideHCID 866688142-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine

Product 1

HCID 68165247N2-[2-chloro-4-(dimethylphosphoryl)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

Procedure

This compound can be prepared as described in Example 80 by reacting 2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine with 2-chloro-4-(dimethylphosphoryl)-aniline.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-2e61c6610f4b4ab680d81be7fe4ad35a
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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