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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1472066Generated: October 31, 2026

(4-Amino-3-chlorophenyl)dimethylphosphine oxide → N2-[2-chloro-4-(dimethylphosphoryl)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

https://huagongshe.com/reaction/1472066

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Amino-3-chlorophenyl)dimethylphosphine oxideHCID 67052677—
Reactant2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amineHCID 86668814—
ProductN2-[2-chloro-4-(dimethylphosphoryl)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamineHCID 68165247—

Reaction Steps

This compound can be prepared as described in Example 80 by reacting 2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine with 2-chloro-4-(dimethylphosphoryl)-aniline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09012462B2
Source datasetuspto-grants-2015_04
ORD IDord-2e61c6610f4b4ab680d81be7fe4ad35a
Source noteuspto-grants-2015_04