HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N3-[4-(diethylphosphoryl)-2-methoxyphenyl]-N5-[2-(propan-2-ylsulfonyl)phenyl]pyridazine-3,5-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(Dipropylphosphoryl)-2-methoxyaniline | HCID 67052710 | — |
| Reactant | 6-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]pyridazin-4-amine | HCID 86668808 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | N3-[4-(diethylphosphoryl)-2-methoxyphenyl]-N5-[2-(propan-2-ylsulfonyl)phenyl]pyridazine-3,5-diamine | HCID 68165253 | — |
Reaction Steps
To a solution of 6-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]pyridazin-4-amine (prepared in Example 73: 0.02 mmol) and 4-(Dipropylphosphoryl)-2-methoxyaniline (0.7 mmol) in 1 mL of 2-Methoxy ethanol, is added 1 mL of 2.5M HCl in Ethanol. The reaction mixture is heated in a sealed tube at 140 degree until formation of the desired compound. The reaction mixture is filtered through a syringe filter and can be purified by Prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012462B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-b6d7134ce609419cb445bc156a6ad974 |
| Source note | uspto-grants-2015_04 |