Hydrochloric Acid → N3-[4-(diethylphosphoryl)-2-methoxyphenyl]-N5-[2-(propan-2-ylsulfonyl)phenyl]pyridazine-3,5-diamine
Reaction equation
Cl[C:2]1[N:7]=[N:6][CH:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:3]=1.[CH2:21]([P:24]([C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[C:31]([O:36][CH3:37])[CH:30]=1)([CH2:26][CH2:27]C)=[O:25])[CH2:22]C.Cl>COCCO.C(O)C>[CH2:21]([P:24]([C:29]1[CH:35]=[CH:34][C:32]([NH:33][C:2]2[N:7]=[N:6][CH:5]=[C:4]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:3]=2)=[C:31]([O:36][CH3:37])[CH:30]=1)([CH2:26][CH3:27])=[O:25])[CH3:22]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 6-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]pyridazin-4-amine (prepared in Example 73: 0.02 mmol) and 4-(Dipropylphosphoryl)-2-methoxyaniline (0.7 mmol) in 1 mL of 2-Methoxy ethanol, is added 1 mL of 2.5M HCl in Ethanol. The reaction mixture is heated in a sealed tube at 140 degree until formation of the desired compound. The reaction mixture is filtered through a syringe filter and can be purified by Prep-HPLC.
Sources & evidence
- ORD record
- ord-b6d7134ce609419cb445bc156a6ad974
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09012462B2
Reaction notes
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