Hydrochloric Acid → HCID 13101077, compound

HRID 1472141Notes

Reaction equation

HRID 1472141 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11](=[O:19])[NH:12][CH2:13][C:14]([O:16]CC)=[O:15].[OH-].[K+].Cl>O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11](=[O:19])[NH:12][CH2:13][C:14]([OH:16])=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 43385006HCID 43385006, compound

Product 1

HCID 13101077HCID 13101077, compoundYield 82.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

The compound was synthesized by hydrolysis method. 100 mg of ethyl 2-(3-benzo[d]thiazole-2-ylureido)acetate and 60 mg of KOH were added to 10 ml of water, and subjected to reflux under 100° C. for 2 hours. The obtained reaction mixture were stirred at room temperature for 30 minutes, and cooled in ice-bath. Then, 1 ml of strong hydrochloric acid was added thereto, to acidify the obtained reaction mixture. 74 mg of 2-(3-benzo[d]thiazole-2-ylureido)acetic acid was produced in white solid phase.

Workup

  1. customThe compound was synthesized by hydrolysis method
  2. customThe obtained reaction mixture
  3. temperaturecooled in ice-bath
  4. customthe obtained reaction mixture

Sources & evidence

ORD record
ord-35b55b8e4af2426bbead14ef01da655f
Source dataset
uspto-grants-2015_04
Patent number
US09012481B2

Reaction notes

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