反应详情

温度

120 °C

N-(benzo[d]thiazole-2-yl)-2-cyanoacetamide (0.1 g), NH4Cl (5.0 eq, 0.1 g), and NaN3 (5.2 eq, 0.13 g) were dissolved on 2.1 mL of DMF (dimethylformamide), and heated at 120° C. for 6 hours. DMF was removed under reduced pressure distillation, and 10 ml of water and 5% NaOH solution were added thereto. The aqueous layer was washed with 15 ml of Et2O, and treated with activated carbon. To the obtained reaction mixture, 10% aqueous hydrochloric acid, making the solution with pH 2. The obtained reaction mixture was extracted with methylene chloride, to produce N-(benzo[d]thiazole-2-yl)-2-(2H-tetrazole-5-yl)acetamide (20%, 21 mg) in light yellow solid phase.

1. customDMF was removed under reduced pressure distillation, and 10 ml of water and 5% NaOH solution
2. additionwere added
3. washThe aqueous layer was washed with 15 ml of Et2O
4. additiontreated with activated carbon
5. customTo the obtained reaction mixture, 10% aqueous hydrochloric acid
6. customThe obtained reaction mixture
7. extractionwas extracted with methylene chloride