Neopentyl alcohol → HCID 58465906, compound

HRID 1472482Notes

Reaction equation

HRID 1472482 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[CH2:23]([OH:28])[C:24]([CH3:27])([CH3:26])[CH3:25].[F:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[N:34][CH:35]=1>>[F:29][C:30]1[CH:31]=[C:32]([C:2]2[CH:3]=[C:4]3[C@:15]4([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]4)[C:14]4[CH:13]=[C:12]([O:28][CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[N:11]=[CH:10][C:9]=4[O:8][C:5]3=[CH:6][CH:7]=2)[CH:33]=[N:34][CH:35]=1

Participants

4

Reactant 3

HCID 6404Neopentyl alcoholHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 58465879(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 58465906HCID 58465906, compound

Procedure

The title compound was synthesized by steps analogous to those described in Method A4, but using Intermediate 10B, neopentyl alcohol, and 5-fluoropyridin-3-ylboronic acid.

Sources & evidence

ORD record
ord-ba592a4a6509490eb90a989bda601037
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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