Neopentyl alcohol → HCID 58465945, compound

HRID 1472483Notes

Reaction equation

HRID 1472483 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[CH2:23]([OH:28])[C:24]([CH3:27])([CH3:26])[CH3:25].[N:29]1[CH:34]=[CH:33][CH:32]=[C:31](B(O)O)[CH:30]=1>>[CH2:23]([O:28][C:12]1[N:11]=[CH:10][C:9]2[O:8][C:5]3[C:4]([C@:15]4([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]4)[C:14]=2[CH:13]=1)=[CH:3][C:2]([C:31]1[CH:30]=[N:29][CH:34]=[CH:33][CH:32]=1)=[CH:7][CH:6]=3)[C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 6404Neopentyl alcoholHCID 27343783-Pyridinylboronic acidHCID 58465879(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 58465945HCID 58465945, compound

Procedure

The title compound was synthesized by steps analogous to those described in Method A4, but using Intermediate 10B, neopentyl alcohol, and pyridin-3-ylboronic acid.

Sources & evidence

ORD record
ord-c360b4a96e76426c82113d0016cfa46d
Source dataset
uspto-grants-2015_04
Patent number
US09012446B2

Reaction notes

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