Hydrochloric Acid → HCID 6415827, compound

HRID 1472722Notes

Reaction equation

HRID 1472722 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=[O:12])=[CH:5][CH:4]=1.[N:13](OCCC(C)C)=[O:14].Cl>CO>[OH:14]/[N:13]=[C:8]1/[C:9](=[O:12])[C:10]2[C:6]([CH2:7]/1)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 3340366-Methoxy-1-Indanone

Product 1

HCID 6415827HCID 6415827, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

6-methoxy-2,3-dihydro-1H-inden-1-one (17.2 g, 106 mmol) was dissolved in methanol (700 mL). The mixture was heated to 40° C., then isoamyl nitrite (30 mL, 220 mmol) and concentrated hydrochloric acid (17 mL) were added. The reaction mixture was stirred at 40° C. for 2 hours. After cooled to room temperature, the precipitate was collected by filtration and dried under high vacuum to obtain product (10.0 g, yield 50%).

Workup

  1. temperatureAfter cooled to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-abfc1ffb15af451eb047822324f8acb9
Source dataset
uspto-grants-2015_04
Patent number
US09012646B2

Reaction notes

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