Ammonium formate → (R)-5-(2-Amino-1-(tert-butyldimethylsilyloxy)ethyl)-8-hydroxyquinolin-2(1H)-one formate

関与物質

反応条件

反応手順

Palladium on activated carbon (0.4 g, 10% w/w) was added to a suspension of (R)-5-(2-azido-1-(tert-butyldimethylsilyloxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one (2.05 g, 4.60 mmol) and ammonium formate (2.87 g, 63 mmol) in methanol (50 mL). The reaction mixture was heated at 80° C. for 1 hour and then filtered through celite, washing with water. The reaction mixture was concentrated under reduced pressure. The resultant solid was washed with water, triturated with ethyl acetate and collected by filtration to afford the title compound (1.32 g, 86%).

情報源と証拠