反应详情

温度

80 °C

Palladium on activated carbon (0.4 g, 10% w/w) was added to a suspension of (R)-5-(2-azido-1-(tert-butyldimethylsilyloxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one (2.05 g, 4.60 mmol) and ammonium formate (2.87 g, 63 mmol) in methanol (50 mL). The reaction mixture was heated at 80° C. for 1 hour and then filtered through celite, washing with water. The reaction mixture was concentrated under reduced pressure. The resultant solid was washed with water, triturated with ethyl acetate and collected by filtration to afford the title compound (1.32 g, 86%).

1. filtrationfiltered through celite
2. washwashing with water
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. washThe resultant solid was washed with water
5. customtriturated with ethyl acetate
6. filtrationcollected by filtration