Ethyl 4-bromobenzoate → HCID 786449, compound

HRID 1472812Notes

Reaction equation

HRID 1472812 reaction equation
C(O[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)C.[CH3:13][N:14]([CH3:18])[CH2:15][CH2:16][NH2:17]>>[Br:11][C:8]1[CH:7]=[CH:6][C:5]([C:4]([NH:17][CH2:16][CH2:15][N:14]([CH3:18])[CH3:13])=[O:12])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 22043Ethyl 4-bromobenzoateHCID 66053N,N-Dimethylethylenediamine

Product 1

HCID 786449HCID 786449, compound

Conditions

Temperature
150 °C

Procedure

A microwave vial containing 4-bromo-benzoic acid ethyl ester (1 g, 4.36 mmol) and N,N-dimethylethylenediamine (2.37 g, 21.38 mmol) was heated under microwave radiation (150° C., 10 min). The volatiles were removed under rotary evaporation and the crude was used in the next step without further purification. Yield: 1.18 g, 100%. LCMS method: 2, RT: 1.93 min; MI: 271-273 [M+1].

Workup

  1. customThe volatiles were removed under rotary evaporation
  2. customthe crude was used in the next step without further purification

Sources & evidence

ORD record
ord-1c811b6b4c7f4e1e86fbdae669acd583
Source dataset
uspto-grants-2015_04
Patent number
US09012633B2

Reaction notes

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