反应详情

A 4 mL vial was charged with SiliaCat DPP-Pd (0.1 equivalent., 26 mg, purchased from Silicycle). Solutions of Example 73A (20 mg, 0.07 mmol) in ethanol (1.0 mL) and 2,3,4-trifluorophenylboronic acid (14 mg, 0.08 mmol) in ethanol (0.3 mL) were added followed by 1 M aqueous Cs2CO3 (0.21 mL). The mixture was heated (Synthos 3000 Anton Paar microwave reaction system) for 30 minutes at 120° C., then filtered and concentrated. The residue was purified by reverse phase HPLC to provide the title compound. MS (ESI+) m/z 343 (M+H)+.

1. temperatureThe mixture was heated
2. filtrationfiltered
3. concentrationconcentrated
4. customThe residue was purified by reverse phase HPLC