HRID1473003

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7912

Diisopropylamine

C6H15N

结构：CS(=O)(=O)OCCC(c1ccccc1)c1cc(Br)ccc1OCc1ccccc1

HCID56849004

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)N(CCC(c1ccccc1)c1cc(Br)ccc1OCc1ccccc1)C(C)C

HCID12972415

3-[2-(Benzyloxy)-5-bromophenyl]-3-phenyl-N,N-di(propan-2-yl)propan-1-amine

C28H34BrNO

结构：CC(C)N(CC[C@H](c1ccccc1)c1cc(Br)ccc1OCc1ccccc1)C(C)C

HCID24885301

(3R)-3-[2-(Benzyloxy)-5-bromophenyl]-3-phenyl-N,N-di(propan-2-yl)propan-1-amine

C28H34BrNO

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

100 g 3-(2-(benzyloxy)-5-bromophenyl)-3-phenylpropyl methanesulfonate of formula (D) and 400 ml diisopropyl amine and 100 ml water under closed reaction condition in SSR autoclave for 48 to 50 hours. The reaction mass was cooled to 0° C. to 5° C. followed by filtration and then washing with 25 ml water. After distillation of solvent completely under vacuum and work up with MDC and water in acidic pH and basic afforded title compound N,N-Diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine of formula (E) in residue form.

WORKUP

后处理

customreaction condition in SSR autoclave for 48 to 50 hours
temperatureThe reaction mass was cooled to 0° C. to 5° C.
filtrationfollowed by filtration
washwashing with 25 ml water
distillationAfter distillation of solvent completely under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1297e710f272457ba0db711cb760599a
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09012678B2
来源说明: uspto-grants-2015_04

反应 SMILES

CS(O[CH2:6][CH2:7][CH:8]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=O)=O.[CH:30]([NH:33][CH:34]([CH3:36])[CH3:35])([CH3:32])[CH3:31]>O>[CH:30]([N:33]([CH2:6][CH2:7][C@@H:8]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:34]([CH3:36])[CH3:35])([CH3:32])[CH3:31].[CH:30]([N:33]([CH2:6][CH2:7][CH:8]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:34]([CH3:36])[CH3:35])([CH3:32])[CH3:31]