Diisopropylamine → 3-(2-(Benzyloxy)-5-bromophenyl)-N,N-diisopropyl-3-phenylpropan-1-amine

Participants

Reaction Steps

100 g 3-(2-(benzyloxy)-5-bromophenyl)-3-phenylpropyl methanesulfonate of formula (D) and 400 ml diisopropyl amine and 100 ml water under closed reaction condition in SSR autoclave for 48 to 50 hours. The reaction mass was cooled to 0° C. to 5° C. followed by filtration and then washing with 25 ml water. After distillation of solvent completely under vacuum and work up with MDC and water in acidic pH and basic afforded title compound N,N-Diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine of formula (E) in residue form.

Provenance & Evidence