反应详情

温度

70 °C

A 250-mL round-bottomed flask was charged with 4-chloro-2-iodoaniline (6.189 g, 24.42 mmol), 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (7.62 g, 36.6 mmol), potassium carbonate (13.50 g, 98 mmol), and Pd(dppf) Cl2CH2Cl2 (0.997 g, 1.221 mmol). The flask was flushed with Ar, then 1,4-dioxane (61.0 mL) and water (20.35 mL) were added in sequence. A reflux condenser was attached, and the flask was heated to 70° C. for 4 h. After being cooled to room temperature, the mixture was diluted with water and EtOAc, which resulted in an emulsion (a small amount of brine was added to clear the emulsion). The layers were separated, and the aq. layer was extracted with EtOAc (twice). The combined organic extracts were dried over sodium sulfate, filtered and concentrated. The residue was partially purified by chromatography on silica gel (30 to 80% EtOAc/Heptane). The partially purified product was taken up in a boiling mixture of heptane (100 mL) and EtOAc (5 mL) to give a murky solution. A 250 mL flask containing the solid was charged with heptane (100 mL). The mixture was cooled to room temperature after 3 h, then the solid was collected by filtration, washed with heptane (3×50 mL), and dried under a stream of N2 for 20 min to give 4-chloro-2-(1-methyl-1H-pyrazol-5-yl)aniline (3.732 g, 17.97 mmol) as a light purple solid. 1H NMR (400 MHz, DMSO-d6) δ ppm=7.50 (d, J=1.9 Hz, 1H), 7.16 (dd, J=2.6, 8.7 Hz, 1H), 7.02 (d, J=2.5 Hz, 1H), 6.78 (d, J=8.7 Hz, 1H), 6.29 (d, J=1.8 Hz, 1H), 5.07 (s, 2H), 3.65 (s, 3H). m/z (ESI) 208.2 (M+H)+.

1. customThe flask was flushed with Ar
2. addition1,4-dioxane (61.0 mL) and water (20.35 mL) were added in sequence
3. customA reflux condenser was attached
4. temperatureAfter being cooled to room temperature
5. additionthe mixture was diluted with water and EtOAc, which
6. customresulted in an emulsion (a small amount of brine
7. additionwas added
8. customThe layers were separated
9. extractionthe aq. layer was extracted with EtOAc (twice)
10. dry with materialThe combined organic extracts were dried over sodium sulfate
11. filtrationfiltered
12. concentrationconcentrated
13. customThe residue was partially purified by chromatography on silica gel (30 to 80% EtOAc/Heptane)
14. additionThe partially purified product was taken up in a boiling mixture of heptane (100 mL) and EtOAc (5 mL)
15. customto give a murky solution
16. additionA 250 mL flask containing the solid
17. temperatureThe mixture was cooled to room temperature after 3 h
18. filtrationthe solid was collected by filtration
19. washwashed with heptane (3×50 mL)
20. dry with materialdried under a stream of N2 for 20 min