HRID1473334

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CC=C(c2cc(C(F)(F)F)ccc2-c2cccc3cc(S(=O)(=O)Nc4ccncn4)ccc23)CC1

HCID86687369

未命名化合物

结构：COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccc(C(F)(F)F)cc4Cl)cccc3c2)cc1

HCID86687387

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccc(C(F)(F)F)cc4C4=CCN(C(=O)OC(C)(C)C)CC4)cccc3c2)cc1

HCID86687388

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in an analogous manner to that of intermediate Y, except that 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)naphthalene-2-sulfonamide was used instead of 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)naphthalene-2-sulfonamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4f162b8e1c6491d89309cd06928ece4
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09012443B2
来源说明: uspto-grants-2015_04

反应 SMILES

N1C=CC(NS(C2C=C3C(=CC=2)C(C2C=CC(C(F)(F)F)=CC=2[C:31]2[CH2:36][CH2:35][N:34]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:33][CH:32]=2)=CC=C3)(=O)=O)=NC=1.Cl[C:45]1[CH:50]=[C:49]([C:51]([F:54])([F:53])[F:52])[CH:48]=[CH:47][C:46]=1[C:55]1[CH:64]=[CH:63][CH:62]=[C:61]2[C:56]=1[CH:57]=[CH:58][C:59]([S:65]([N:68]([CH2:74][C:75]1[CH:80]=[CH:79][C:78]([O:81][CH3:82])=[CH:77][CH:76]=1)[C:69]1[S:70][CH:71]=[CH:72][N:73]=1)(=[O:67])=[O:66])=[CH:60]2>>[CH3:82][O:81][C:78]1[CH:77]=[CH:76][C:75]([CH2:74][N:68]([C:69]2[S:70][CH:71]=[CH:72][N:73]=2)[S:65]([C:59]2[CH:60]=[C:61]3[C:56](=[CH:57][CH:58]=2)[C:55]([C:46]2[CH:47]=[CH:48][C:49]([C:51]([F:52])([F:53])[F:54])=[CH:50][C:45]=2[C:31]2[CH2:36][CH2:35][N:34]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:33][CH:32]=2)=[CH:64][CH:63]=[CH:62]3)(=[O:67])=[O:66])=[CH:80][CH:79]=1