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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1473334Generated: October 30, 2026

tert-butyl 4-(2-(6-(N-(pyrimidin-4-yl)sulfamoyl)naphthalen-1-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate → Tert-butyl 4-(2-(6-(N-(4-methoxybenzyl)-N-(thiazol-2-YL)sulfamoyl)naphthalen-1-YL)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

https://huagongshe.com/reaction/1473334

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl 4-(2-(6-(N-(pyrimidin-4-yl)sulfamoyl)naphthalen-1-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylateHCID 86687369—
Reactant5-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-YL)naphthalene-2-sulfonamideHCID 86687387—
ProductTert-butyl 4-(2-(6-(N-(4-methoxybenzyl)-N-(thiazol-2-YL)sulfamoyl)naphthalen-1-YL)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylateHCID 86687388—

Reaction Steps

The title compound was prepared in an analogous manner to that of intermediate Y, except that 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)naphthalene-2-sulfonamide was used instead of 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)naphthalene-2-sulfonamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09012443B2
Source datasetuspto-grants-2015_04
ORD IDord-d4f162b8e1c6491d89309cd06928ece4
Source noteuspto-grants-2015_04