HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 4-(2-(6-(N-(pyrimidin-4-yl)sulfamoyl)naphthalen-1-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate → Tert-butyl 4-(2-(6-(N-(4-methoxybenzyl)-N-(thiazol-2-YL)sulfamoyl)naphthalen-1-YL)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 4-(2-(6-(N-(pyrimidin-4-yl)sulfamoyl)naphthalen-1-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 86687369 | — |
| Reactant | 5-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-YL)naphthalene-2-sulfonamide | HCID 86687387 | — |
| Product | Tert-butyl 4-(2-(6-(N-(4-methoxybenzyl)-N-(thiazol-2-YL)sulfamoyl)naphthalen-1-YL)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 86687388 | — |
Reaction Steps
The title compound was prepared in an analogous manner to that of intermediate Y, except that 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)naphthalene-2-sulfonamide was used instead of 5-(2-chloro-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)naphthalene-2-sulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012443B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-d4f162b8e1c6491d89309cd06928ece4 |
| Source note | uspto-grants-2015_04 |