反应详情

温度

180 °C

A microwave vial was charged with 1-methylpiperazine (1.371 ml, 12.35 mmol) and 4-bromo-3-fluorobenzotrifluoride (1.000 ml, 4.12 mmol), and was heated under microwave irradiation at 180° C. for 90 minutes. The reaction was concentrated under a vacuum, and the solids were then filtered and washed with DCM (the solids contained minor amounts of product but were disposed of). The filtrate was then concentrated under a vacuum to yield 1-(2-bromo-5-(trifluoromethyl)phenyl)-4-methylpiperazine. The material was carried forward without further purification. m/z (ESI) 323.0 (M+H)+.

1. concentrationThe reaction was concentrated under a vacuum
2. filtrationthe solids were then filtered
3. washwashed with DCM (the solids
4. concentrationThe filtrate was then concentrated under a vacuum