Trifluoroacetic acid → HCID 86687678, compound

Participants

Reaction Steps

Tert-butyl 3-methyl-4-(6-(N-(pyrimidin-4-yl)sulfamoyl)isoquinolin-1-yl)piperazine-1-carboxylate (0.043 g, 0.089 mmol) was dissolved in DCM (0.887 ml) and TFA (0.1 ml, 1.298 mmol) was added. The reaction was stirred for one hour at room temperature. The reaction was concentrated, triturated with ether, and filtered. The solids were washed with ether and vacuum dried to afford 1-(2-methylpiperazin-1-yl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide 2,2,2-trifluoroacetate as a yellow solid. (ESI) 385.3 (M+H)+.

Provenance & Evidence