Trifluoroacetic acid → HCID 86687678, compound

HRID 1473613Notes

Reaction equation

HRID 1473613 reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([S:18](=[O:27])(=[O:26])[NH:19][C:20]4[CH:25]=[CH:24][N:23]=[CH:22][N:21]=4)=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>C(Cl)Cl>[F:38][C:37]([F:40])([F:39])[C:35]([OH:41])=[O:36].[CH3:1][CH:2]1[CH2:3][NH:4][CH2:5][CH2:6][N:7]1[C:8]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([NH:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][N:21]=3)(=[O:27])=[O:26])=[CH:15][CH:16]=2)[CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86687680HCID 86687680, compound

Product 1

HCID 86687678HCID 86687678, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 3-methyl-4-(6-(N-(pyrimidin-4-yl)sulfamoyl)isoquinolin-1-yl)piperazine-1-carboxylate (0.043 g, 0.089 mmol) was dissolved in DCM (0.887 ml) and TFA (0.1 ml, 1.298 mmol) was added. The reaction was stirred for one hour at room temperature. The reaction was concentrated, triturated with ether, and filtered. The solids were washed with ether and vacuum dried to afford 1-(2-methylpiperazin-1-yl)-N-(pyrimidin-4-yl)isoquinoline-6-sulfonamide 2,2,2-trifluoroacetate as a yellow solid. (ESI) 385.3 (M+H)+.

Workup

  1. concentrationThe reaction was concentrated
  2. customtriturated with ether
  3. filtrationfiltered
  4. washThe solids were washed with ether and vacuum
  5. customdried

Sources & evidence

ORD record
ord-e044014017ff4b049e9904cc0bce77af
Source dataset
uspto-grants-2015_04
Patent number
US09012443B2

Reaction notes

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