反应详情

A solution of 1,4-dibromo-2,5-dimethoxybenzene (7.00 g, 23.65 mmol) in 100 mL ether was cooled to −78° C. and was treated with n-butyllithium (10.41 ml, 26.0 mmol). After stirring for 10 minutes, the reaction mixture was quenched with DMF (3.66 ml, 47.3 mmol), and the cooling bath was removed. After stirring for an additional hour, LC/MS showed mostly product, so the reaction mixture was washed with 1N citric acid solution, the organics dried over MgSO4 and concentrated. The crude product was carried forward in step two without purification. (M+H)+=245.1.

1. customthe cooling bath was removed
2. stirringAfter stirring for an additional hour
3. washso the reaction mixture was washed with 1N citric acid solution
4. dry with materialthe organics dried over MgSO4
5. concentrationconcentrated
6. customThe crude product was carried forward in step two without purification