HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,4-Thiadiazol-2-amine → 4-(4-chloro-2-methoxyphenyl)-N-(1,3,4-thiadiazol-2-yl)quinazoline-7-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | 5-Amino-1,2,4-thiadiazole | HCID 290274 | — |
| Reactant | Perfluorophenyl 4-(2-chloro-3'-fluoro-5-methoxy-[1,1'-biphenyl]-4-yl)quinazoline-7-sulfonate | HCID 86687767 | — |
| Reactant | Perfluorophenyl 4-(4-chloro-2-methoxyphenyl)quinazoline-7-sulfonate | HCID 86687771 | — |
| Product | 4-(4-chloro-2-methoxyphenyl)-N-(1,3,4-thiadiazol-2-yl)quinazoline-7-sulfonamide | HCID 86687775 | — |
Reaction Steps
The title compound was prepared in an analogous manner to that of EXAMPLE 521, except that perfluorophenyl 4-(4-chloro-2-methoxyphenyl)quinazoline-7-sulfonate and 1,3,4-thiadiazol-2-amine were used instead of perfluorophenyl 4-(2-chloro-3′-fluoro-5-methoxy-[1,1′-biphenyl]-4-yl)quinazoline-7-sulfonate and 1,2,4-thiadiazol-5-amine to afford 4-(4-chloro-2-methoxyphenyl)-N-(1,3,4-thiadiazol-2-yl)quinazoline-7-sulfonamide as a yellow solid. (ESI) 434.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012443B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-7b704934cf154fccbef12699c86580a9 |
| Source note | uspto-grants-2015_04 |