Trifluoroacetic acid → HCID 86678434, compound

HRID 1473720Notes

Reaction equation

HRID 1473720 reaction equation
C(OC([NH:8][C@H:9]([C:20]([OH:22])=[O:21])[CH2:10]/[CH:11]=[C:12](/[CH2:16][CH2:17][CH2:18][F:19])\[C:13]([OH:15])=[O:14])=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[NH2:8][C@H:9]([C:20]([OH:22])=[O:21])[CH2:10]/[CH:11]=[C:12](/[CH2:16][CH2:17][CH2:18][F:19])\[C:13]([OH:15])=[O:14].[F:23][C:24]([F:29])([F:28])[C:25]([O-:27])=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86678433HCID 86678433, compound

Product 1

HCID 86678434HCID 86678434, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(Z)—(S)-5-[(tert-Butoxycarbonyl)amino]-2-(3-fluoropropyl)hex-2-enedioic acid (10.0 mg, 0.03 mmol) was stirred in a mixture of trifluoroacetic acid (1.0 mL) and dichloromethane (1.0 mL) at r.t. for 4 h. After that the mixture was concentrated under reduced pressure, the residue was taken up in water (10 mL) and the solution was lyophilised. Yield: 6.0 mg, 0.02 mmol, 56%.

Workup

  1. concentrationAfter that the mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d6f5b7530a0a4f90a98c49e092f2a726
Source dataset
uspto-grants-2015_04
Patent number
US09017645B2

Reaction notes

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