反应详情

温度

75 °C

To a solution 2-chloro-4-methoxypyrimidine (2 g, 13.8 mmol) in ethoxyethanol (50 mL) was added 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (1.7 g, 10.6 mmol). The reaction was warmed to 75° C. for 16 h, cooled, and diluted with water and EtOAc. The layers were separated, and the aqueous layer was extracted with EtOAc (4×). The combined organics were dried (MgSO4), and concentrated to give a near colorless solid which was homogeneous by analytical HPLC analysis and was used without further purification.

1. temperaturecooled
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with EtOAc (4×)
4. dry with materialThe combined organics were dried (MgSO4)
5. concentrationconcentrated
6. customto give a near colorless solid which
7. customwas used without further purification