HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1473886Generated: October 30, 2026
Thionyl Chloride → 8-(Chloromethyl)imidazo[1,2-a]pyridine
https://huagongshe.com/reaction/1473886
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Imidazo[1,2-a]pyridin-8-ylmethanol | HCID 11029987 | — |
| Product | 8-(Chloromethyl)imidazo[1,2-a]pyridine | HCID 21661582 | — |
Reaction Steps
A mixture of imidazo[1,2-a]pyridin-8-ylmethanol (800 mg) and excess thionyl chloride was stirred at 70-80° C. for 8 h. Excess thionyl chloride was removed under vacuum. The residue was then diluted with toluene and evaporated. This procedure was repeated 3 times.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09018210B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-76526a3247e240ae85b244aac7857c6b |
|---|
| Source note | uspto-grants-2015_04 |
|---|
