Hydrochloric Acid → HCID 86645030, compound

Participants

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol; 2-bromothiazole (0.27 mL, 3.05 mmol), 5-amino-2-methoxyphenol (212 mg, 1.52 mmol) and 37% HCl solution (0.26 mL, 3.05 mmol) in 10% aqueous EtOH solution (5 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 62% yield (210 mg).

Provenance & Evidence