Hydrochloric Acid → HCID 86645030, compound

HRID 1473970Notes

Reaction equation

HRID 1473970 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:15][CH3:16])=[C:12]([OH:14])[CH:13]=1.Cl>CCO>[CH3:16][O:15][C:11]1[CH:10]=[CH:9][C:8]([NH:7][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[CH:13][C:12]=1[OH:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 743145-Amino-2-methoxyphenolHCID 764302-Bromothiazole

Product 1

HCID 86645030HCID 86645030, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol; 2-bromothiazole (0.27 mL, 3.05 mmol), 5-amino-2-methoxyphenol (212 mg, 1.52 mmol) and 37% HCl solution (0.26 mL, 3.05 mmol) in 10% aqueous EtOH solution (5 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 62% yield (210 mg).

Sources & evidence

ORD record
ord-24d3f5a7ff2a468797ab20dbf9f5bd0f
Source dataset
uspto-grants-2015_04
Patent number
US09018209B2

Reaction notes

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