5-Amino-2-chlorophenol → HCID 68491242, compound

HRID 1474016Notes

Reaction equation

HRID 1474016 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](Cl)[N:3]=1.[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([Cl:17])=[C:14]([OH:16])[CH:15]=1>CCO>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([Cl:17])=[C:14]([OH:16])[CH:15]=2)[N:3]=1

Participants

4

Reactant 2

HCID 806765-Amino-2-chlorophenolHCID 3457522-Chloro-4-aminopyrimidine

Product 1

HCID 68491242HCID 68491242, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 4-amino-2-chloropyrimidine (70 mg, 0.5 mmol) and 5-amino-2-chlorophenol (78 mg, 0.5 mmol) in 10% aqueous EtOH (2 mL) was heated at 90° C. for 18 h. The title compound was obtained in 47% yield a (60 mg) and used for the next step without additional purification.

Sources & evidence

ORD record
ord-9cfb367ae55148408382e349af3d64d2
Source dataset
uspto-grants-2015_04
Patent number
US09018209B2

Reaction notes

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