5-Amino-2-methylphenol → HCID 68488712, compound

HRID 1474017Notes

Reaction equation

HRID 1474017 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:15]=[C:14]([OH:16])[C:13]([CH3:17])=[CH:12][CH:11]=1>CCO>[NH2:1][C:2]1[N:7]=[C:6]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([CH3:17])=[C:14]([OH:16])[CH:15]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 178185-Amino-2-methylphenolHCID 2233322-Amino-4-chloropyrimidine

Product 1

HCID 68488712HCID 68488712, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-amino-4-chloropyrimidine (70 mg, 0.5 mmol) and 5-amino-o-cresol (67 mg, 0.5 mmol) in 10% aqueous EtOH (2 mL) was heated at 90° C. for 18 h. The title compound was obtained in 94% yield a (110 mg) and used for the next step without additional purification.

Sources & evidence

ORD record
ord-176e13de12054db983252129b18d9a07
Source dataset
uspto-grants-2015_04
Patent number
US09018209B2

Reaction notes

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