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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474017Generated: November 1, 2026

5-Amino-2-methylphenol → HCID 68488712, compound

https://huagongshe.com/reaction/1474017

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Amino-2-methylphenolHCID 17818—
Reactant2-Amino-4-chloropyrimidineHCID 223332—
SolventEthanolHCID 702—
ProductHCID 68488712HCID 6848871294%

Reaction Conditions

Temperature90 °C

Reaction Steps

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-amino-4-chloropyrimidine (70 mg, 0.5 mmol) and 5-amino-o-cresol (67 mg, 0.5 mmol) in 10% aqueous EtOH (2 mL) was heated at 90° C. for 18 h. The title compound was obtained in 94% yield a (110 mg) and used for the next step without additional purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018209B2
Source datasetuspto-grants-2015_04
ORD IDord-176e13de12054db983252129b18d9a07
Source noteuspto-grants-2015_04