Nitrate(1-), oxo- → HCID 66644716, compound

HRID 1474124Notes

Reaction equation

HRID 1474124 reaction equation
[Na].[CH2:2]([N:9]1[CH:13]([C:14]([OH:16])=O)[CH2:12][CH2:11][S:10]1(=[O:18])=[O:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:19][CH:20]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:21]([OH:25])[C:22]([NH2:24])=[O:23].O[NH-].O=[N-]>>[NH2:24][C:22](=[O:23])[C:21](=[O:25])[CH:20]([NH:19][C:14]([CH:13]1[CH2:12][CH2:11][S:10](=[O:18])(=[O:17])[N:9]1[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:16])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

6

Reactant 5

HCID 3001380Nitrate(1-), oxo-HCID 5360545SodiumHCID 138823553-Amino-2-hydroxy-4-phenylbutanamideHCID 58280447HCID 58280447, compoundHCID 178514248HCID 178514248, compound

Product 1

HCID 66644716HCID 66644716, compound

Procedure

Coupling of the sodium salt of 2-benzyl-1,1-dioxo-isothiazolidine-3-carboxylic acid with 3-amino-2-hydroxy-4-phenylbutanamide and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide.

Sources & evidence

ORD record
ord-30093c56b09f45dbb0e4847d4b1b2a98
Source dataset
uspto-grants-2015_04
Patent number
US09018206B2

Reaction notes

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