Acetic Acid → 2-Chloro-5-methoxybenzene-1-sulfonyl chloride

Temperature

0 °C

To a 3-neck flask equipped with a dry ice condenser was added acetic acid (80 mL) and copper chloride (0.8 g). The mixture was cooled to 0° C., sulfur dioxide (5 mL) was condensed into the reaction flask, and then the reaction mixture was stirred for 30 minutes. To a separate 200 mL round-bottom flask was added concentrated hydrochloric acid (32 mL), acetic acid (8 mL) and 2-chloro-5-methylaniline hydrochloride (3.2 g, 16 mmol). This mixture was cooled to 0° C., and sodium nitrite (1.25 g, 18.1 mmol) in water (8 mL) was added dropwise while keeping the temperature below 10° C. The reaction mixture was stirred for 30 minutes and then added dropwise to the sulfur dioxide solution. The resulting reaction mixture was stirred at room temperature for 1 h. Water was added dropwise, and a tan solid precipitated. The solid was isolated by filtration and washed with water to afford 2.5 g the title compound. 1H NMR (CDCl3) δ 7.64 (d, 1H), 7.52 (d, 1H), 7.17 (d, 1H), 3.89 (s, 3H).

1. customTo a 3-neck flask equipped with a dry ice condenser
2. customcondensed into the reaction flask
3. temperatureThis mixture was cooled to 0° C.
4. customthe temperature below 10° C
5. stirringThe reaction mixture was stirred for 30 minutes
6. customThe resulting reaction mixture
7. stirringwas stirred at room temperature for 1 h
8. customa tan solid precipitated
9. customThe solid was isolated by filtration
10. washwashed with water

ORD record

ord-63c1a175046f4ca2b0b3f568ad5ee3f3

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09018228B2