Trifluoroacetic acid → HCID 59568680, compound

HRID 1474291Notes

Reaction equation

HRID 1474291 reaction equation
CC([CH:5]1[CH2:10][N:9]([CH2:11][CH:12]2[C:21]3[C:16](=[CH:17][C:18]([Br:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[CH2:15][CH2:14][O:13]2)[CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:24][C:18]1[CH:17]=[C:16]2[C:21](=[CH:20][C:19]=1[O:22][CH3:23])[CH:12]([CH2:11][N:9]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:10]1)[O:13][CH2:14][CH2:15]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86647315HCID 86647315, compound

Product 1

HCID 59568680HCID 59568680, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1,1-dimethylethyl-4-{[6-bromo-7-(methyloxy)-3,4-dihydro-1H-isochromen-1-yl]methyl}piperazine-1-carboxylate (150 mg, 0.34 mmol) in 5 mL of DCM was added 5 mL of TFA and the mixture was stirred at room temperature for 1 h. The reaction was concentrated and the 1-{[6-bromo-7-(methyloxy)-3,4-dihydro-1H-isochromen-1-yl]methyl}piperazine was directly used in next step.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-716f598afdee4d85a97e6af8d7680b91
Source dataset
uspto-grants-2015_04
Patent number
US09018211B2

Reaction notes

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