反应详情

To a solution of 4,7-dimethyl-5-vinyl-2-benzofuran-1(3H)-one (0.4 g, 2.1 mmol) in 60 mL of DCM was slowly added mCPBA (85%, 0.7 g, 4.2 mmol) at 0° C. After warming to room temperature, the mixture was stirred for 48 hours. The mixture was washed subsequently with saturated NaHCO3, aqueous Na2SO3, 5% NaOH and brine. The mixture was concentrated and the residue was purified by column chromatography to afford 4,7-dimethyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one as white solid.

1. customat 0° C
2. washThe mixture was washed subsequently with saturated NaHCO3, aqueous Na2SO3, 5% NaOH and brine
3. concentrationThe mixture was concentrated
4. customthe residue was purified by column chromatography