1,4-Dioxane hydrochloride → 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

HRID 1474390Notes

Reaction equation

HRID 1474390 reaction equation
CC([CH:5]1[CH2:10][N:9]([CH2:11][CH:12]2[C:21]3[C:16](=[C:17]([Br:22])[CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14][O:13]2)[CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[Br:22][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[CH2:15][CH2:14][O:13][CH:12]2[CH2:11][N:9]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 866473201,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate

Product 1

HCID 666439161-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (480 mg, 1.2 mmol) in 10 mL of DCM was added 10 mL of 4N HCl/dioxane, and then stirred at room temperature for 2 hours. The solvents was removed under vacuum to afford 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine.

Workup

  1. customThe solvents was removed under vacuum

Sources & evidence

ORD record
ord-3a256193d52d4df298e1db2247c67291
Source dataset
uspto-grants-2015_04
Patent number
US09018211B2

Reaction notes

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