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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1474390Generated: November 4, 2026

1,4-Dioxane hydrochloride → 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

https://huagongshe.com/reaction/1474390

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
Reactant1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylateHCID 86647320—
SolventDichloromethaneHCID 6344—
Product1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazineHCID 66643916—

Reaction Steps

A solution of 1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (480 mg, 1.2 mmol) in 10 mL of DCM was added 10 mL of 4N HCl/dioxane, and then stirred at room temperature for 2 hours. The solvents was removed under vacuum to afford 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09018211B2
Source datasetuspto-grants-2015_04
ORD IDord-3a256193d52d4df298e1db2247c67291
Source noteuspto-grants-2015_04