HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5,5'-[piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl)]bis(4-fluoro-2-benzofuran-1(3H)-one)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-fluoro-5-(oxiran-2-yl)-3H-2-benzofuran-1-one | HCID 59568672 | — |
| Solvent | Carbon Dioxide | HCID 280 | — |
| Product | 5,5'-[piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl)]bis(4-fluoro-2-benzofuran-1(3H)-one) | HCID 49802224 | — |
Reaction Steps
5,5′-[piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl)]bis(4-fluoro-2-benzofuran-1(3H)-one) was prepared in a similar fashion to that described for the synthesis of EXAMPLE 2 starting from 4-fluoro-5-oxiranyl-3H-isobenzofuran-1-one and piperazine. The isomers of the product were obtained via SFC resolution (Column Chiralcel OJ-H 100*4.6 mm I.D., Sum; Mobile phase: 40% iso-propanol (0.05% DEA) in CO2; Flow rate: 4.5 mL/min; Wavelength: 220 nm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09018211B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-43ac6e5a420a45ceb3bca1293cf6e153 |
| Source note | uspto-grants-2015_04 |