反应详情

5,5′-[piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl)]bis(4-fluoro-2-benzofuran-1(3H)-one) was prepared in a similar fashion to that described for the synthesis of EXAMPLE 2 starting from 4-fluoro-5-oxiranyl-3H-isobenzofuran-1-one and piperazine. The isomers of the product were obtained via SFC resolution (Column Chiralcel OJ-H 100*4.6 mm I.D., Sum; Mobile phase: 40% iso-propanol (0.05% DEA) in CO2; Flow rate: 4.5 mL/min; Wavelength: 220 nm).