Trifluoroacetic acid → 2-(4-(Benzyloxy)-2-chlorophenyl)acetic acid

HRID 1474674Notes

Reaction equation

HRID 1474674 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[C:11]([Cl:23])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[C:11]([Cl:23])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70856298Tert-butyl [4-(benzyloxy)-2-chlorophenyl]acetate

Product 1

HCID 42417462-(4-(Benzyloxy)-2-chlorophenyl)acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl [4-(benzyloxy)-2-chlorophenyl]acetate (1.0 g, 3.00 mmol) in DCM (8 ml) was treated with TFA (6.94 ml, 90 mmol) and the mixture stirred at RT for 30 min. The volatiles were removed in vacuo to afford the title compound. LC/MS (m/z): 299 (M+Na)+.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-df1afe5a9ea3452984e7934b92d68d9c
Source dataset
uspto-grants-2015_04
Patent number
US09018224B2

Reaction notes

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