反应详情

1-(azetidin-1-yl)-2-[4-(benzyloxy)-2-methoxyphenyl]ethanone (1.26 g, 4.05 mmol) was dissolved in ethanol (10 ml) and palladium hydroxide on carbon (20%) (284 mg, 0.405 mmol) added. The mixture was stirred under an atmosphere of hydrogen gas at RT overnight. The mixture was filtered and the filtrate concentrated under reduced pressure. The reside was purified by column chromatography using a Biotage RP C18 cartridge (30 g) using a gradient eluant of 0-30% water: acetonitrile+0.05% formic acid to afford the title compound. LC/MS (m/z): 222 (M+H)+.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. customThe reside was purified by column chromatography