HRID1474722
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 35 °C
PROCEDURE
实验过程
Tert-butyl 2-(2,6-difluoro-4-(2-((1S,2R)-2-(1-(5-methoxypyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethoxy)phenyl)acetate (1.87 g, 3.71 mmol) was dissolved in DCM (10 ml) and hydrochloric acid (9.28 ml, 4 M solution in dioxane, 37.1 mmol) was added. The mixture was stirred at 35° C. for 5 h. The volatiles were removed under reduced pressure to afford the titled compound. LC/MS (m/z): 448 (M+H)+.
WORKUP
后处理
- customThe volatiles were removed under reduced pressure