tert-Butyl (2R)-2-methylpiperazine-1-carboxylate → HCID 71003221, compound

HRID 1475286Notes

Reaction equation

HRID 1475286 reaction equation
C(OC(N1CCNC[C@H]1C)=O)(C)(C)C.[C:15]([O:19][C:20]([N:22]1[CH2:27][C@H:26](COC)[N:25]([CH2:31][C:32]([OH:34])=[O:33])[CH2:24][C@H:23]1[CH3:35])=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([CH2:31][C:32]([OH:34])=[O:33])[CH2:24][C@H:23]1[CH3:35])=[O:21])([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 10262201tert-Butyl (2R)-2-methylpiperazine-1-carboxylateHCID 71003241HCID 71003241, compound

Product 1

HCID 71003221HCID 71003221, compound

Procedure

Prepared from (R)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester in an analogous manner to that described for (2R,5R)-4-carboxymethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester in Preparations 13 and 14. 1H NMR (Me-d3-OD): 4.51-4.42 (1H, m), 4.10-3.99 (1H, m), 3.58 (1H, d), 3.53-3.39 (2H, m), 3.28 (1H, s), 2.99-2.82 (2H, m), 1.49 (9H, s), 1.36 (3H, d).

Sources & evidence

ORD record
ord-3d88038a69ba4259b6316bb6eff19cf7
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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