Hydrochloric Acid → HCID 131732779, compound

HRID 1475310Notes

Reaction equation

HRID 1475310 reaction equation
C(OC([N:8]1[C:12]2=[CH:13][N:14]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:15](=[O:17])[CH:16]=[C:11]2[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH2:18]([N:14]1[C:15](=[O:17])[CH:16]=[C:11]2[CH2:10][CH2:9][NH:8][C:12]2=[CH:13]1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86723941HCID 86723941, compound

Product 1

HCID 131732779HCID 131732779, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 6-benzyl-5-oxo-2,3,5,6-tetrahydro-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester (0.050 g, 0.15 mmol), 1,4-dioxane (1 mL) and a solution of hydrogen chloride in 1,4-dioxane (4 M, 0.5 mL) was stirred at 20° C. for 18 h, then was evaporated in vacuo. The residue was dissolved in MeOH then re-evaporated and the azeotrope process repeated to give the title compound as a pale green glass, used without further purification. MS: [M+H]+=227.

Workup

  1. customwas evaporated in vacuo
  2. dissolutionThe residue was dissolved in MeOH
  3. customthen re-evaporated

Sources & evidence

ORD record
ord-31881e89e6774404a2e3a74f63688a27
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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